Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.53 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7719042 | 0.90 | CYSLTR1 (0.58) | GPBAR1ALOX5CYSLTR1CYSLTR2 | |
| SCHEMBL10543991 | 0.89 | CYSLTR1 (0.65) | GPBAR1ALOX5CYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL9829080 | 0.88 | CYSLTR1 (0.64) | GPBAR1ALOX5CYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL6090157 | 0.87 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL7006454 | 0.87 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL7717086 | 0.87 | CYSLTR1 (0.56) | GPBAR1ALOX5CYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL9057089 | 0.86 | CYSLTR1 (0.53) | GPBAR1ALOX5CYSLTR1CYSLTR2FFAR1 | |
| SCHEMBL10421994 | 0.86 | CYSLTR1 (0.63) | CYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL7451794 | 0.85 | CYSLTR1 (0.45) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL10421901 | 0.84 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2FFAR1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0315399-B1 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE POULENC RORER INT (US) | 1996-01-10 | — | — | EP | disclosed |
| EP-0315399-A2 | Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-05-10 | — | — | EP | disclosed |