⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5604846 | 0.82 | — | — | |
| SCHEMBL7402032 | 0.82 | — | — | |
| SCHEMBL28743528 | 0.76 | — | — | |
| SCHEMBL28743929 | 0.74 | — | — | |
| SCHEMBL821115 | 0.72 | — | — | |
| SCHEMBL4487307 | 0.72 | — | — | |
| SCHEMBL4487319 | 0.72 | — | — | |
| SCHEMBL7500639 | 0.71 | — | — | |
| SCHEMBL1214816 | 0.70 | — | — | |
| SCHEMBL7128088 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471493-B1 | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PROD (US) | 1996-05-22 | — | — | EP | claimed |
| US-5179216-A | Anticholesterol agents and atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-12 | — | — | US | claimed |
| EP-0471493-A1 | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-02-19 | — | — | EP | claimed |
| EP-0471493-B1 | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PROD (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5399697-A | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |
| US-5380853-A | Atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-10 | — | — | US | disclosed |
| US-5281714-A | Enzyme inhibitors or antioxidants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-01-25 | — | — | US | disclosed |
| US-5179216-A | Anticholesterol agents and atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-12 | — | — | US | disclosed |
| US-5179216-A | Anticholesterol agents and atherosclerosis | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-01-12 | — | — | US | disclosed |
| EP-0471493-A1 | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-02-19 | — | — | EP | disclosed |