SCHEMBL9022707

SCHEMBL9022707

C[C@]12CCC(=O)NC1=CC[C@@H]1[C@H]2CC[C@]2(C)C(C(=O)NC(c3ccccc3)c3ccc(Cl)cc3)CC[C@@H]12

nearest known ligand 0.68

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 14/20 0.68
SRD5A1 P18405 7/20 0.56
AR P10275 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9022704 1.00 SRD5A2 (0.68) SRD5A2SRD5A1AR
SCHEMBL9022781 0.95 SRD5A2 (0.70) SRD5A2SRD5A1AR
SCHEMBL9022772 0.95 SRD5A2 (0.70) SRD5A2SRD5A1AR
SCHEMBL9022712 0.93 SRD5A2 (0.65) SRD5A2SRD5A1AR
SCHEMBL9022717 0.93 SRD5A2 (0.65) SRD5A2SRD5A1AR
SCHEMBL9022590 0.91 SRD5A2 (0.64) SRD5A2SRD5A1
SCHEMBL9022593 0.91 SRD5A2 (0.64) SRD5A2SRD5A1
SCHEMBL9022560 0.87 SRD5A2 (0.59) SRD5A2SRD5A1
SCHEMBL9022750 0.84 SRD5A2 (0.63) SRD5A2SRD5A1
SCHEMBL9022745 0.84 SRD5A2 (0.63) SRD5A2SRD5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0484094-B1 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO CO (JP) 1996-06-26 EP disclosed
US-5302621-A Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use SANKYO COMPANY, LIMITED (JP) 1994-04-12 US disclosed
EP-0484094-A2 Azasteroid compounds for the treatment of prostatic hypertrophy, their preparation and use Sankyo Company Limited (JP) 1992-05-06 EP disclosed