Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.79 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15021754 | 0.88 | PDE10A (1.00) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL899338 | 0.88 | PDE10A (1.00) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14727012 | 0.86 | PDE10A (0.82) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14721104 | 0.85 | PDE10A (0.81) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14723420 | 0.85 | PDE10A (0.81) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14721459 | 0.83 | PDE10A (1.00) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14722769 | 0.83 | PDE10A (1.00) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14723100 | 0.82 | PDE10A (0.81) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14726819 | 0.82 | PDE10A (0.81) | PDE10ANR1I2CYP2C9CYP3A4 | |
| SCHEMBL14722184 | 0.82 | PDE10A (0.81) | PDE10ANR1I2CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044561-A2 | 2-ALKOXY PYRIMIDINE PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |