Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.44 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9006238 | 1.00 | TBXA2R (0.44) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9023533 | 0.99 | TBXA2R (0.43) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9006272 | 0.99 | TBXA2R (0.43) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9023689 | 0.98 | TBXA2R (0.44) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9006228 | 0.98 | TBXA2R (0.44) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9006180 | 0.96 | TBXA2R (0.46) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9023990 | 0.96 | TBXA2R (0.46) | TBXA2RPTGDRTBXAS1HTTALDH1A1 | |
| SCHEMBL9006184 | 0.92 | PTGDR (0.47) | TBXA2RPTGDRTBXAS1HTT | |
| SCHEMBL9025339 | 0.92 | PTGDR (0.47) | TBXA2RPTGDRTBXAS1HTT | |
| SCHEMBL9024374 | 0.91 | PTGDR (0.47) | TBXA2RPTGDRTBXAS1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0367130-B1 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-10-02 | — | — | EP | disclosed |
| US-5264453-A | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-11-23 | — | — | US | disclosed |
| US-5130323-A | PYRROLIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-14 | — | — | US | disclosed |
| EP-0367130-A2 | Pyrrolidine derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-09 | — | — | EP | disclosed |