Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17361365 | 0.88 | POLB (0.46) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL1150081 | 0.84 | POLB (0.53) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL15964752 | 0.81 | TP53 (0.49) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL12797178 | 0.81 | POLB (0.45) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL1259028 | 0.81 | HCAR2 (0.66) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL15069078 | 0.78 | NPSR1 (0.46) | POLBKMT2ANPSR1L3MBTL1HCAR2 | |
| SCHEMBL6366232 | 0.78 | HCAR2 (0.68) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL20521912 | 0.78 | HCAR2 (0.50) | POLBKMT2ATP53THRBNPSR1 | |
| SCHEMBL12703567 | 0.77 | HCAR2 (0.67) | POLBKMT2ATP53THRBHCAR2 | |
| SCHEMBL1233899 | 0.77 | HCAR2 (0.64) | POLBKMT2ATP53THRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725783-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011905-A1 | 2-(PYRAZOL-3-YL)CARBAPENEM DERIVATIVES | SMITHKLINE BEECHAM PLC (GB) | 1995-05-04 | — | — | WO | disclosed |