Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NEK2 | P51955 | 3/20 | 0.45 |
| ▸ | PLK1 | P53350 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466256 | 0.83 | KDM4E (0.56) | CYP1A2CYP2C9KDM4EKMT2AMEN1 | |
| SCHEMBL8830493 | 0.83 | KDM4E (0.56) | CYP1A2CYP2C9KDM4EKMT2AMEN1 | |
| SCHEMBL7466251 | 0.83 | KDM4E (0.56) | CYP1A2CYP2C9KDM4EKMT2AMEN1 | |
| SCHEMBL28436908 | 0.74 | KDM4E (0.76) | CYP1A2CYP2C9CYP3A4KDM4EKMT2A | |
| SCHEMBL3156151 | 0.74 | KMT2A (0.59) | KDM4EKMT2AMEN1PDE4APDE4B | |
| SCHEMBL1388456 | 0.74 | MCL1 (0.51) | CYP1A2CYP2C9CYP3A4KDM4EKMT2A | |
| SCHEMBL1388454 | 0.74 | MCL1 (0.51) | CYP1A2CYP2C9CYP3A4KDM4EKMT2A | |
| SCHEMBL7471065 | 0.74 | MCL1 (0.51) | CYP1A2CYP2C9CYP3A4KDM4EKMT2A | |
| SCHEMBL28056488 | 0.72 | KDM4E (0.57) | KDM4EKMT2AMEN1MAPTEGFR | |
| SCHEMBL28440427 | 0.71 | TP53 (0.67) | CYP1A2CYP2C9CYP3A4KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0558950-B1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA SPA (IT) | 1996-12-04 | — | — | EP | disclosed |
| US-5436235-A | 3-aryl-glycidic ester derivatives | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-07-25 | — | — | US | disclosed |
| EP-0558950-A1 | 3-aryl-glycidic ester derivatives and process for their preparation | PHARMACIA S.p.A. (IT) | 1993-09-08 | — | — | EP | disclosed |