Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028070 | 0.86 | NPC1 (0.38) | NPC1RAB9AMAOBL3MBTL1KMT2A | |
| SCHEMBL9028672 | 0.85 | NPC1 (0.38) | NPC1RAB9AMAOBL3MBTL1KMT2A | |
| SCHEMBL9028155 | 0.85 | NPC1 (0.38) | NPC1RAB9AMAOBL3MBTL1KMT2A | |
| SCHEMBL9029053 | 0.85 | NPC1 (0.39) | NPC1RAB9AMAOBL3MBTL1KMT2A | |
| SCHEMBL9028667 | 0.81 | MAOB (0.37) | NPC1RAB9AMAOBGAA | |
| SCHEMBL9028219 | 0.79 | MAOB (0.36) | NPC1RAB9AMAOBGAASMN1; SMN2 | |
| SCHEMBL9028487 | 0.78 | — | — | |
| SCHEMBL9028802 | 0.77 | MAOB (0.36) | NPC1RAB9AMAOBGAASMN1; SMN2 | |
| SCHEMBL9027463 | 0.76 | HMGCR (0.38) | NPC1RAB9AKMT2A | |
| SCHEMBL9029119 | 0.72 | MAOB (0.38) | NPC1RAB9AMAOBL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |