⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9028316 | 1.00 | — | — | |
| SCHEMBL9027533 | 0.91 | MEN1 (0.36) | — | |
| SCHEMBL9028785 | 0.91 | — | — | |
| SCHEMBL9027542 | 0.91 | MEN1 (0.36) | — | |
| SCHEMBL9027776 | 0.89 | — | — | |
| SCHEMBL9027769 | 0.89 | — | — | |
| SCHEMBL9027443 | 0.87 | HMGCR (0.37) | — | |
| SCHEMBL9027435 | 0.87 | HMGCR (0.37) | — | |
| SCHEMBL9722422 | 0.86 | HMGCR (0.35) | — | |
| SCHEMBL9722427 | 0.86 | HMGCR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |