Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA4 | P22748 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL9028864 | 1.00 | NR1H2 (0.42) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| SCHEMBL8394418 | 0.95 | NR1H2 (0.46) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| SCHEMBL8394421 | 0.95 | NR1H2 (0.46) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| Piperazine SCHEMBL9028956 | 0.90 | CA1 (0.52) | NR1H2NR1H3SIGMAR1CA1CA2 | |
| Piperazine SCHEMBL9028960 | 0.90 | CA1 (0.52) | NR1H2NR1H3SIGMAR1CA1CA2 | |
| SCHEMBL8571416 | 0.89 | NR1H2 (0.44) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| SCHEMBL4846692 | 0.85 | NR1H2 (0.44) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| SCHEMBL4846682 | 0.85 | NR1H2 (0.44) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| SCHEMBL15020095 | 0.84 | NR1H2 (0.47) | NR1H2NR1H3SIGMAR1PARP1CA1 | |
| SCHEMBL8229902 | 0.84 | CA1 (0.56) | NR1H2NR1H3SIGMAR1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703905-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1996-04-03 | — | — | EP | disclosed |