Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | RAD52 | P43351 | 2/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL19211094 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| Bromide SCHEMBL9694366 | 1.00 | KDM4E (0.53) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL29601334 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL29601800 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL29601298 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL29602006 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL29601881 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL9155741 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL9722985 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL29602007 | 0.98 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277270-B1 | N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions | PUETTER MEDICE CHEM PHARM (DE) | 1996-12-27 | — | — | EP | disclosed |
| EP-0526737-B1 | Process for the preparation of dihydroxyacetone | BASF AG (DE) | 1995-03-15 | — | — | EP | disclosed |
| EP-0568872-A1 | Process for the preparation of dihydroxyacetone | BASF Aktiengesellschaft (DE) | 1993-11-10 | — | — | EP | disclosed |
| EP-0526737-A1 | Process for the preparation of dihydroxyacetone | BASF Aktiengesellschaft (DE) | 1993-02-10 | — | — | EP | disclosed |
| EP-0516194-A2 | Pharmaceutical compositions containing cationic surfactants | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1992-12-02 | — | — | EP | disclosed |
| EP-0513878-A2 | Pharmaceutical compositions containing cationic surfactants | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1992-11-19 | — | — | EP | disclosed |
| US-5143917-A | Cationic tensides for controlling infections | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1992-09-01 | — | — | US | disclosed |
| US-5133973-A | Quaternary Ammonium Cationic Surfactants, Antimetabolites | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1992-07-28 | — | — | US | disclosed |
| US-5118808-A | Pharmaceutical preparations | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1992-06-02 | — | — | US | disclosed |
| US-5112844-A | Micelles | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1992-05-12 | — | — | US | disclosed |
| US-4965357-A | CATIONIC TENSIDES, ANTIMETABOLITES | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1990-10-23 | — | — | US | disclosed |
| US-4894454-A | BACTERICIDES | MEDICE CHEM.-PHARM. FABRIK, PUTTER GMBH & CO., KG (DE) | 1990-01-16 | — | — | US | disclosed |
| US-4882435-A | CATIONIC TENSIDES; THIADIAZOLIUM SALTS | MEDICE CHEM.-PHARM. FABRIK (DE) | 1989-11-21 | — | — | US | disclosed |
| US-4877883-A | CATIONIC SURFACTANTS | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) | 1989-10-31 | — | — | US | disclosed |
| US-4874850-A | CATIONIC TENSIDES IN MICELLES WITH HYDROPHOBIC PEPTIDES; DRUG DELIVERY | MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. (DE) | 1989-10-17 | — | — | US | disclosed |
| US-4870174-A | CATIONIC SURFACTANTS, SMALL CRITICAL MICELLE CONCENTRATIONS | MEDICE CHEM.-PHARM. FABRIK (DE) | 1989-09-26 | — | — | US | disclosed |
| EP-0277270-A2 | N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1988-08-10 | — | — | EP | disclosed |
| EP-0262343-A2 | N-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1988-04-06 | — | — | EP | disclosed |
| EP-0260428-A2 | Cationic surfactants and pharmaceutical compositions containing them | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1988-03-23 | — | — | EP | disclosed |
| EP-0258672-A2 | Cationic surfactants and pharmaceutical compositions containing them | MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG (DE) | 1988-03-09 | — | — | EP | disclosed |