Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198265 | 0.98 | HDAC1 (0.51) | HDAC1HDAC6SIRT2SIRT1KMT2A | |
| SCHEMBL5082657 | 0.94 | PTGER4 (0.48) | HDAC1HDAC6SIRT2SIRT1KMT2A | |
| SCHEMBL9597233 | 0.89 | HDAC1 (0.52) | HDAC1HDAC6SIRT2SIRT1KMT2A | |
| SCHEMBL9204479 | 0.89 | HDAC1 (0.51) | HDAC1HDAC6KMT2AHDAC8PTGER4 | |
| SCHEMBL9597610 | 0.89 | PTGER4 (0.47) | HDAC1HDAC6KMT2APTGER4PTGER2 | |
| SCHEMBL9598013 | 0.89 | HDAC1 (0.43) | HDAC1HDAC6KMT2AHDAC8HSD17B10 | |
| SCHEMBL9598020 | 0.88 | HDAC1 (0.57) | HDAC1HDAC6KMT2AHDAC8HSD17B10 | |
| SCHEMBL9598300 | 0.87 | HDAC1 (0.48) | HDAC1HDAC6SIRT2SIRT1KMT2A | |
| SCHEMBL9208304 | 0.87 | HDAC1 (0.43) | HDAC1HDAC6KMT2AHDAC8HSD17B10 | |
| SCHEMBL9598441 | 0.86 | HDAC1 (0.44) | HDAC1HDAC6KMT2AHDAC8HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478822-A | Tetrahydrobenzazepine derivatives which inhibit lipoxygenase | PFIZER INC. (US) | 1995-12-26 | — | — | US | claimed |
| EP-0591255-B1 | TETRAHYDROBENZAZEPINE DERIVATIVES WHICH INHIBIT LIPOXYGENASE | PFIZER (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5478822-A | Tetrahydrobenzazepine derivatives which inhibit lipoxygenase | PFIZER INC. (US) | 1995-12-26 | — | — | US | disclosed |