Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 13/20 | 0.66 |
| ▸ | CYSLTR2 | Q9NS75 | 12/20 | 0.66 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032159 | 1.00 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1KDM4EMEN1 | |
| SCHEMBL6583310 | 0.91 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| Hydrogen Sulfide SCHEMBL9818430 | 0.90 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL9031842 | 0.88 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1KDM4EALDH1A1 | |
| SCHEMBL9033119 | 0.86 | GPBAR1 (0.85) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL9033055 | 0.86 | GPBAR1 (0.85) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL9031839 | 0.85 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL9031944 | 0.85 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL9031837 | 0.85 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL9031363 | 0.85 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397697-B1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RHONE POULENC RORER INT (US) | 1996-08-28 | — | — | EP | disclosed |
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0397697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-07-03 | — | — | EP | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0397697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4?. | RORER INT OVERSEAS (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4920130-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | RORER PHARAMCEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004304-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |