Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 20/20 | 1.00 |
| ▸ | PIP4K2C | Q8TBX8 | 15/20 | 1.00 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | MITF | O75030 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903178 | 0.85 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL903184 | 0.81 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL903180 | 0.80 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL903202 | 0.75 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL903196 | 0.74 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL10202432 | 0.73 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL903197 | 0.68 | HTT (1.00) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL18732783 | 0.67 | HTT (0.62) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL17717005 | 0.65 | HTT (0.71) | HTTPIP4K2CPAX8MEN1LMNA | |
| SCHEMBL17717013 | 0.65 | HTT (0.71) | HTTPIP4K2CPAX8MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044993-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF TREATING OR PREVENTING NEURODEGENERATIVE DISEASES OR DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-04-05 | — | — | WO | disclosed |