Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 11/20 | 0.56 |
| ▸ | MAPT | P10636 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | NPC1 | O15118 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15715208 | 0.76 | SMPD3 (0.42) | PIM1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL4331224 | 0.74 | PIM1 (0.74) | PIM1KDR | |
| SCHEMBL4332411 | 0.73 | PIM1 (1.00) | PIM1MAPTKDM4ENPSR1MAPK1 | |
| SCHEMBL4333400 | 0.73 | FYN (0.78) | PIM1MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL10308911 | 0.72 | SCN5A (0.48) | — | |
| SCHEMBL102963 | 0.72 | PIM1 (0.58) | PIM1RAB9AMAPTKDM4ENPC1 | |
| SCHEMBL4333215 | 0.71 | PIM1 (0.55) | PIM1FYN | |
| SCHEMBL4340556 | 0.70 | PIK3CG (0.65) | PIM1MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL13500713 | 0.70 | PIM1 (0.47) | PIM1RAB9AMAPTKDM4ENPC1 | |
| SCHEMBL16629016 | 0.69 | SMPD3 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041524-A1 | HYDRAZONOPYRAZOLONES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN (MDC) (DE) | 2012-04-05 | — | — | WO | disclosed |