Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033137 | 1.00 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2CNR2MAPT | |
| SCHEMBL5674922 | 0.82 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTADORA3 | |
| SCHEMBL9032005 | 0.82 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTADORA3 | |
| SCHEMBL5674913 | 0.82 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTADORA3 | |
| SCHEMBL10219837 | 0.78 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2CNR2MAPT | |
| SCHEMBL9032458 | 0.77 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2CNR2MAPT | |
| SCHEMBL9032465 | 0.77 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2CNR2MAPT | |
| SCHEMBL6973188 | 0.76 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2CNR2MAPT | |
| SCHEMBL2563234 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2CNR2MAPT | |
| SCHEMBL2565667 | 0.76 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2CNR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528734-B1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1996-10-23 | — | — | EP | disclosed |
| US-5330999-A | Diabetes, obesity | ADIR ET COMPAGNIE (FR) | 1994-07-19 | — | — | US | disclosed |
| US-5296605-A | 2,4-thiazolidinedione compounds | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5266582-A | Antidiabetic agents | ADIR ET COMPAGNIE (FR) | 1993-11-30 | — | — | US | disclosed |
| EP-0528734-A1 | Thiazolidin-2,4-dione derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-02-24 | — | — | EP | disclosed |