Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034489 | 0.94 | KMT2A (0.51) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9032295 | 0.84 | KMT2A (0.55) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL9400449 | 0.83 | KMT2A (0.54) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9034662 | 0.76 | KMT2A (0.49) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9033393 | 0.73 | KMT2A (0.50) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9032216 | 0.72 | KMT2A (0.55) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL23649331 | 0.71 | KMT2A (0.67) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9032701 | 0.71 | KMT2A (0.51) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL12509429 | 0.70 | KMT2A (0.73) | KMT2APOLBCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL12801144 | 0.70 | KMT2A (0.54) | KMT2APOLBCYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442348-B1 | Imidazole compounds, process for preparation, medicaments based on these compounds and some intermediates | HOECHST AG (DE) | 1996-07-17 | — | — | EP | disclosed |
| US-5356922-A | Treatment of disturbances in microcirculation | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-18 | — | — | US | disclosed |
| US-5232922-A | Cardiovascular disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-03 | — | — | US | disclosed |
| EP-0442348-A2 | Imidazole compounds, process for preparation, medicaments based on these compounds and some intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-21 | — | — | EP | disclosed |