Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.52 |
| ▸ | CACNA1F | O60840 | 7/20 | 0.51 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.51 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.51 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034242 | 1.00 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9033394 | 1.00 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9034192 | 0.96 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9034599 | 0.94 | MAPT (0.62) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9034602 | 0.94 | MAPT (0.62) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9032386 | 0.91 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9032348 | 0.91 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9032182 | 0.89 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9032131 | 0.89 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT | |
| SCHEMBL9033575 | 0.89 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0474129-B1 | 1,4-Dihydropyridine derivatives and process for preparing the same | ACHIWA KAZUO (JP) | 1996-12-18 | — | — | EP | disclosed |
| US-5336774-A | 1,4-dihydropyridine 3,5 carboxyl compounds | ACHIWA KAZUO (JP) | 1994-08-09 | — | — | US | disclosed |
| US-5234821-A | Process for preparing 1,4 dihydropyridine compounds | ACHIWA KAZUO (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0474129-A2 | 1,4-Dihydropyridine derivatives and process for preparing the same | Achiwa, Kazuo (JP) | 1992-03-11 | — | — | EP | disclosed |