Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 13/20 | 0.66 |
| ▸ | HTR1B | P28222 | 10/20 | 0.66 |
| ▸ | HTR2A | P28223 | 4/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8704883 | 0.96 | HTR1D (0.70) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| 4-Chloro-Benzoic Acid SCHEMBL9035256 | 0.90 | HTR1D (0.66) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL1333497 | 0.85 | HTR1D (0.71) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8705402 | 0.85 | HTR1D (0.70) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL7805150 | 0.85 | HTR1D (0.77) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8705195 | 0.85 | HTR1D (0.70) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL8707722 | 0.84 | HTR1D (0.69) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL9299582 | 0.83 | HTR1D (0.69) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 | |
| SCHEMBL9332881 | 0.83 | HTR1D (0.59) | HTR1DHTR1BHTR2AMEN1KMT2A | |
| SCHEMBL4688960 | 0.83 | HTR1D (0.68) | HTR1DHTR1BHTR2ASLC6A4TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712397-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004729-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-16 | — | — | WO | disclosed |