Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 1/20 | 0.72 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18168235 | 0.84 | TYRO3 (1.00) | TYRO3DYRK1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL23234494 | 0.69 | SIRT2 (0.60) | KDM4EDAOMEN1GRIN2DGRIN3B | |
| SCHEMBL8478065 | 0.68 | GRIN2D (0.56) | KDM4EMEN1GRIN2DGRIN3BALDH1A1 | |
| SCHEMBL23234575 | 0.67 | GRIN2D (0.54) | KDM4EMEN1GRIN2DGRIN3BALDH1A1 | |
| SCHEMBL2744269 | 0.67 | KDM4E (0.36) | KDM4EDAOGRIN2DGRIN3BGRIN1 | |
| SCHEMBL18128044 | 0.67 | TYRO3 (0.50) | TYRO3DYRK1BKDM4ELMNACYP1A2 | |
| SCHEMBL25272619 | 0.67 | TYRO3 (0.50) | TYRO3DYRK1BKDM4EMEN1ALDH1A1 | |
| SCHEMBL4039587 | 0.66 | TYRO3 (0.41) | TYRO3DYRK1BDAO | |
| SCHEMBL24885835 | 0.65 | TYRO3 (0.49) | TYRO3DYRK1BKDM4E | |
| SCHEMBL30987752 | 0.65 | GRIN2D (0.53) | KDM4EMEN1GRIN2DGRIN3BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0743855-A1 | 8-AZA, 6-AZA AND 6,8-DIAZA-1,4-DIHYDROQUINOXALINE-2,3-DIONES AND THE USE THEREOF AS ANTAGONISTS FOR THE GLYCINE/NMDA RECEPTOR | ACEA PHARMACEUTICALS, INC. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995018616-A2 | 8-AZA, 6-AZA AND 6,8-DIAZA-1,4-DIHYDROQUINOXALINE-2,3-DIONES AND THE USE THEREOF AS ANTAGONISTS FOR THE GLYCINE/NMDA RECEPTOR | ACEA PHARM INC (US) | 1995-07-13 | — | — | WO | disclosed |