Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | IGF1R | P08069 | 6/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454287 | 0.84 | AURKA (0.64) | EGFRIGF1RFLT4KDRUTS2R | |
| SCHEMBL9039890 | 0.77 | MEN1 (0.52) | EGFRIGF1RFLT4KDRHSD17B10 | |
| SCHEMBL18879069 | 0.75 | AURKA (0.48) | UTS2RAURKA | |
| SCHEMBL6525870 | 0.75 | AURKA (0.56) | FLT4AURKA | |
| SCHEMBL6525271 | 0.72 | EGFR (0.59) | EGFRIGF1RUTS2RAURKAKDM4E | |
| SCHEMBL9037748 | 0.72 | AURKA (0.39) | IGF1RKDRUTS2RAURKAKDM4E | |
| SCHEMBL3454522 | 0.71 | AURKA (0.74) | FLT4AURKA | |
| SCHEMBL8103118 | 0.71 | HSD17B10 (0.51) | HSD17B10BACE1PKMKDM4EKDM6B | |
| SCHEMBL407352 | 0.70 | AURKA (0.43) | EGFRIGF1RFLT4KDRUTS2R | |
| SCHEMBL6521513 | 0.70 | AURKA (0.56) | EGFRIGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696590-A1 | Pyrido[2,3-d]pyrimidine derivatives, their preparation and their use as anti-asthma agents | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |