Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAGLA | Q9Y4D2 | 13/20 | 0.59 |
| ▸ | CNR1 | P21554 | 10/20 | 0.59 |
| ▸ | CNR2 | P34972 | 1/20 | 0.58 |
| ▸ | PNLIP | P16233 | 3/20 | 0.58 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | DAGLB | Q8NCG7 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.53 |
| ▸ | LPL | P06858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LIPC | P11150 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | FASN | P49327 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.53 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.53 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.53 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038465 | 1.00 | DAGLA (0.59) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9038460 | 1.00 | DAGLA (0.59) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9031617 | 0.90 | DAGLA (0.60) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9031854 | 0.88 | DAGLA (0.63) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9031552 | 0.86 | DAGLA (0.71) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9266457 | 0.86 | DAGLA (0.71) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9034029 | 0.86 | DAGLA (0.71) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9266461 | 0.86 | DAGLA (0.71) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9259132 | 0.86 | DAGLA (0.71) | DAGLACNR1CNR2PNLIPMGLL | |
| SCHEMBL9032224 | 0.86 | DAGLA (0.71) | DAGLACNR1CNR2PNLIPMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0444482-B1 | Oxetanones | HOFFMANN LA ROCHE (CH) | 1996-01-17 | — | — | EP | disclosed |
| US-5466708-A | Carbamyloxyoxetanone compounds | HOFFMANN-LA ROCHE INC. (US) | 1995-11-14 | — | — | US | disclosed |
| US-5376674-A | Lipase inhibitors | HOFFMAN-LA ROCHE INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5260310-A | Oxetanone compounds and pharmaceutical compositions containing them | HOFFMANN-LA ROCHE INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0444482-A2 | Oxetanones | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-04 | — | — | EP | disclosed |