Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6961612 | 0.99 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL6964955 | 0.87 | SMN1; SMN2 (0.43) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL9037824 | 0.86 | ACKR3 (0.43) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| SCHEMBL9036770 | 0.86 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL15499632 | 0.86 | MAPT (0.48) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| Bromide SCHEMBL6962429 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| Hydrochloric Acid SCHEMBL9219017 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| Hydrochloric Acid SCHEMBL9221358 | 0.85 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| Bromide SCHEMBL6967194 | 0.85 | ACKR3 (0.43) | SMN1; SMN2NPC1RAB9AHTTMAPT | |
| Bromide SCHEMBL6968089 | 0.85 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | claimed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | claimed |