Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15300747 | 0.84 | SLC6A4 (0.53) | SLC6A4SLC6A2SLC6A3HTR6HTR2C | |
| Hydrochloric Acid SCHEMBL17541992 | 0.82 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3HTR6HTR2C | |
| SCHEMBL2114839 | 0.81 | GRIN1 (0.44) | SLC6A4SLC6A2SLC6A3EPHX2 | |
| SCHEMBL17643355 | 0.81 | GRIN1 (0.44) | SLC6A4SLC6A2SLC6A3EPHX2 | |
| SCHEMBL2114840 | 0.81 | GRIN1 (0.44) | SLC6A4SLC6A2SLC6A3EPHX2 | |
| SCHEMBL17643108 | 0.81 | GRIN1 (0.44) | SLC6A4SLC6A2SLC6A3EPHX2 | |
| SCHEMBL2114187 | 0.81 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL2114185 | 0.81 | SLC6A4 (0.59) | SLC6A4SLC6A2SLC6A3HTR2CHTR2B | |
| SCHEMBL24136460 | 0.81 | SLC6A4 (0.56) | SLC6A4SLC6A2SLC6A3HTR6HRH1 | |
| SCHEMBL14704876 | 0.81 | SLC6A4 (0.56) | SLC6A4SLC6A2SLC6A3HTR6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |