SCHEMBL9040899

SCHEMBL9040899

CC1(C)CC(OC(=O)c2ccccc2)CC(C)(C)N1OC1CCC(ON2C(C)(C)CC(OC(=O)c3ccccc3)CC2(C)C)CC1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.71
KMT2A Q03164 2/20 0.64
GAA P10253 2/20 0.59
MEN1 O00255 1/20 0.52
CHRNA7 P36544 3/20 0.51
HTR3E A5X5Y0 1/20 0.51
HTR3B O95264 1/20 0.51
HTR3A P46098 1/20 0.51
HTR3D Q70Z44 1/20 0.51
HTR3C Q8WXA8 1/20 0.51
ALDH1A1 P00352 1/20 0.48
ESR1 P03372 1/20 0.48
HSD17B10 Q99714 1/20 0.48
LMNA P02545 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
APOBEC3A P31941 1/20 0.47
APOBEC3G Q9HC16 1/20 0.47
SCN1A P35498 1/20 0.46
SCN2A Q99250 1/20 0.46
SCN3A Q9NY46 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4812999 0.93 TSHR (0.67) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL9042749 0.89 TSHR (0.68) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL9042515 0.87 TSHR (0.65) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL9590842 0.86 TSHR (0.56) TSHRKMT2AGAAALDH1A1ESR1
SCHEMBL1138721 0.86 KMT2A (0.84) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL7533362 0.86 TSHR (0.75) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL7476120 0.85 TSHR (0.70) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL9440201 0.84 TSHR (0.82) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL1138526 0.84 TSHR (0.82) TSHRKMT2AGAAMEN1CHRNA7
SCHEMBL9043360 0.84 TSHR (0.73) TSHRKMT2AGAAMEN1CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5574162-A CONTAIN REACTIVE FUNCTIONAL GROUP, I.E., HYDROXY, AMINO, ISOCYANATO, GLYCIDYLOXY, TRIHYDROXYSILYL OR TRIALKOXYSILYL, WHICH CAN BE CHEMICALLY ATTACHED TO POLYMER SUBSTRATES CIBA-GEIGY CORPORATION (US) 1996-11-12 US disclosed
EP-0389419-B1 Non-migrating 1-hydrocarbyloxy hindered amine compounds as polymer stabilizers CIBA GEIGY AG (CH) 1996-05-01 EP disclosed
US-5442071-A Photostability CIBA-GEIGY CORPORATION (US) 1995-08-15 US disclosed
US-5359069-A Non-migrating 1-hydrocarbyloxy hindered amine derivatives as polymer stabilizers CIBA-GEIGY CORPORATION (US) 1994-10-25 US disclosed
EP-0389421-B1 Poly(1-hydrocarbyloxy-2,2,6,6-tetraalkylpiperidine) light stabilizers CIBA GEIGY AG (CH) 1994-04-27 EP disclosed
US-5286865-A Contain reactive functional group which can be chemically attached to selected polymer substrates CIBA-GEIGY CORPORATION (US) 1994-02-15 US disclosed
US-5189086-A Polysubstituted N-hydrocarbyloxy hindered amine light stabilizers CIBA-GEIGY CORPORATION (US) 1993-02-23 US disclosed
US-5145893-A Photostability CIBA-GEIGY CORPORATION (US) 1992-09-08 US disclosed
US-5021577-A For polymers CIBA-GEIGY CORPORATION (US) 1991-06-04 US disclosed
EP-0389419-A1 Non-migrating 1-hydrocarbyloxy hindered amine compounds as polymer stabilizers CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed
EP-0389421-A1 Poly(1-hydrocarbyloxy-2,2,6,6-tetraalkylpiperidine) light stabilizers CIBA-GEIGY AG (CH) 1990-09-26 EP disclosed