Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31496106 | 0.88 | NR1H2 (0.54) | NR1H2USP2SMN1; SMN2RECQLGPR119 | |
| SCHEMBL30915773 | 0.83 | NR1H2 (0.60) | NR1H2USP2SMN1; SMN2RECQLGPR119 | |
| SCHEMBL17926099 | 0.83 | NR1H2 (0.60) | NR1H2USP2SMN1; SMN2RECQLGPR119 | |
| SCHEMBL29215623 | 0.83 | NR1H2 (0.60) | NR1H2USP2SMN1; SMN2RECQLGPR119 | |
| SCHEMBL16192303 | 0.79 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL20567011 | 0.79 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL372088 | 0.79 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL904004 | 0.79 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL11957185 | 0.79 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL19597436 | 0.79 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2GPR119HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |