Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 9/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.62 |
| ▸ | KIF11 | P52732 | 5/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20704585 | 1.00 | TP53 (0.66) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL20704712 | 1.00 | TP53 (0.66) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| Parachlorophenol SCHEMBL8510047 | 0.95 | TP53 (0.61) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL11912929 | 0.92 | TP53 (0.64) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL764584 | 0.91 | TP53 (0.67) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL22238481 | 0.90 | TP53 (0.64) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL11912901 | 0.90 | TP53 (0.64) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL16549505 | 0.90 | ABCG2 (0.74) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| SCHEMBL17929671 | 0.90 | ABCG2 (0.79) | TP53MAPTSMN1; SMN2ABCG2ABCB1 | |
| Emvododstat SCHEMBL8509210 | 0.89 | TP53 (0.62) | TP53MAPTSMN1; SMN2ABCG2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435437-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC Therapeutics, Inc. (US) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010138644-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| EP-2139476-A1 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC Therapeutics, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008127714-A1 | ADMINISTRATION OF CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |