Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTTP | P55157 | 14/20 | 0.52 |
| ▸ | NPY2R | P49146 | 2/20 | 0.49 |
| ▸ | APOB | P04114 | 5/20 | 0.49 |
| ▸ | KLRK1 | P26718 | 1/20 | 0.48 |
| ▸ | MICA | Q29983 | 1/20 | 0.48 |
| ▸ | RAET1L | Q5VY80 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL904380 | 1.00 | MTTP (0.52) | MTTPNPY2RAPOBKLRK1MICA | |
| SCHEMBL904386 | 1.00 | MTTP (0.52) | MTTPNPY2RAPOBKLRK1MICA | |
| Hydrochloric Acid SCHEMBL2579600 | 0.99 | MTTP (0.51) | MTTPNPY2RAPOBKLRK1MICA | |
| SCHEMBL12174424 | 0.93 | MTTP (0.51) | MTTPNPY2RAPOBKLRK1MICA | |
| SCHEMBL14748022 | 0.92 | NPY2R (0.51) | MTTPNPY2RAPOBKLRK1MICA | |
| SCHEMBL14748036 | 0.92 | NPY2R (0.51) | MTTPNPY2RAPOBKLRK1MICA | |
| SCHEMBL14748023 | 0.92 | NPY2R (0.51) | MTTPNPY2RAPOBKLRK1MICA | |
| Usistapide SCHEMBL29376869 | 0.91 | NPY2R (0.62) | MTTPNPY2RAPOBKLRK1MICA | |
| Usistapide SCHEMBL803532 | 0.91 | NPY2R (0.62) | MTTPNPY2RAPOBKLRK1MICA | |
| Usistapide SCHEMBL785394 | 0.91 | NPY2R (0.62) | MTTPNPY2RAPOBKLRK1MICA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435406-B1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2013-03-06 | — | — | EP | claimed |
| CN-102448934-B | Resolution of (+-)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate | JANSSEN PHARMACEUTICA NV | 2014-04-02 | — | — | CN | disclosed |
| US-8461341-B2 | Resolution of (±)-methyl phenyl[4-[4-[[[4′(trifluoromethyl)-2-biphenylyl]carbonyl]amino]Phenyl]-1-piperidinyl]acetate | JANSSEN PHARMACEUTICA NV (BE) | 2013-06-11 | — | — | US | disclosed |
| EP-2435406-B1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2013-03-06 | — | — | EP | disclosed |
| CN-102448934-A | Resolution of (+-)-methyl phenyl[4-[4-[[[4'-(trifluoromethyl)-2-biphenylyl]carbonyl]amino]phenyl]-1-piperidinyl]acetate | JANSSEN PHARMACEUTICA NV | 2012-05-09 | — | — | CN | disclosed |
| EP-2435406-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | Janssen Pharmaceutica, N.V. (BE) | 2012-04-04 | — | — | EP | disclosed |
| EP-2435406-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | Janssen Pharmaceutica, N.V. (BE) | 2012-04-04 | — | — | EP | disclosed |
| WO-2010136526-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136526-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136526-A1 | RESOLUTION OF (±)-METHYL PHENYL[4-[4-[[[4'-(TRIFLUOROMETHYL)-2-BIPHENYLYL]CARBONYL]AMINO]PHENYL]-1-PIPERIDINYL]ACETATE | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-02 | — | — | WO | disclosed |