Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL12615227 | 0.95 | — | — | |
| Bicarbonate SCHEMBL2558186 | 0.94 | CA4 (0.60) | — | |
| Bicarbonate SCHEMBL27562247 | 0.94 | CA4 (0.60) | — | |
| Bicarbonate SCHEMBL27889751 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2420 | 0.94 | — | — | |
| Bicarbonate SCHEMBL1332437 | 0.94 | — | — | |
| Bicarbonate SCHEMBL25332008 | 0.89 | CA4 (0.55) | — | |
| Bicarbonate SCHEMBL9247678 | 0.89 | CA1 (0.56) | — | |
| Bicarbonate SCHEMBL16341497 | 0.89 | — | — | |
| Bicarbonate SCHEMBL2945248 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3419974-B1 | PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES | ASCENEURON SA (CH) | 2021-05-05 | — | — | EP | disclosed |
| US-10344021-B2 | Process for the separation of enantiomers of piperazine derivatives | ASCENEURON S A (CH) | 2019-07-09 | — | — | US | disclosed |
| EP-3419974-A1 | PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES | Asceneuron SA (CH) | 2019-01-02 | — | — | EP | disclosed |
| WO-2017144635-A1 | PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES | ASCENEURON S. A. (CH) | 2017-08-31 | — | — | WO | disclosed |
| US-20130172562-A1 | PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE | DR. REDDY'S LABORATORIES, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| EP-2582671-A2 | PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE | Dr. Reddy's Laboratories Ltd. (IN) | 2013-04-24 | — | — | EP | disclosed |
| WO-2011160037-A2 | PROCESS FOR THE PREPARATION OF A SINGLE ENANTIOMER OF 3-AMINOPIPERIDINE DIHYDROCHLORIDE | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-12-22 | — | — | WO | disclosed |
| EP-0420237-B1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | EISAI CO LTD (JP) | 1996-03-06 | — | — | EP | disclosed |
| US-5093366-A | Alpha-reductase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-03-03 | — | — | US | disclosed |
| US-5037852-A | Treating or reverting hair loss, acne or prostatic hypertrophy | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-08-06 | — | — | US | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |
| US-4863963-A | 5-A-REDUCTASE INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0302423-A2 | 1-Phenyl-3-(1-piperazinyl)-1h-indazoles, a process and intermediates for their preparation, and the use thereof as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-02-08 | — | — | EP | disclosed |