Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8649563 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL11682254 | 0.83 | SMN1; SMN2 (0.70) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL3767593 | 0.81 | SMN1; SMN2 (0.72) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL14067268 | 0.79 | SMN1; SMN2 (0.65) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL13002857 | 0.78 | NOTUM (0.65) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL14067050 | 0.78 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL13675761 | 0.75 | TRPV1 (0.65) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL14590670 | 0.75 | TP53 (0.60) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL14148139 | 0.75 | NOTUM (0.60) | SMN1; SMN2MAPTNPC1TP53RAB9A | |
| SCHEMBL1948508 | 0.74 | SMN1; SMN2 (0.80) | SMN1; SMN2MAPTNPC1TP53RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746554-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995023141-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1995-08-31 | — | — | WO | disclosed |