Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.68 |
| ▸ | HSD17B3 | P37058 | 6/20 | 0.67 |
| ▸ | STS | P08842 | 4/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27387801 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL12016810 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL9520347 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL10865339 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL9522917 | 1.00 | HDAC8 (0.69) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL1304627 | 0.98 | PDE4B (0.70) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL22034392 | 0.95 | HDAC8 (0.64) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL4530719 | 0.93 | PDE4B (0.72) | HDAC8HDAC1PDE4BHSD17B3STS | |
| SCHEMBL3171960 | 0.91 | PDE4B (0.79) | HDAC8HDAC1PDE4BMAPTL3MBTL1 | |
| SCHEMBL8984256 | 0.91 | HDAC8 (0.58) | HDAC8HDAC1PDE4BHSD17B3STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594563-B1 | 2-acylaminopropanol-type glucosylceramide synthase inhibitors | GENZYME CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-0339599-B1 | Process for producing acylaromatic compounds | SUMITOMO CHEMICAL CO (JP) | 1996-08-21 | — | — | EP | disclosed |
| US-5235068-A | Using a boron trifluoride complex catalyst to react an aromatic compound and anhydride or acid | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1993-08-10 | — | — | US | disclosed |
| EP-0299379-B1 | PENTADIENAMIDE PAF-ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-21 | — | — | EP | disclosed |
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |
| EP-0339599-A2 | Process for producing acylaromatic compounds | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1989-11-02 | — | — | EP | disclosed |
| EP-0299379-A1 | Pentadienamide PAF-antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-18 | — | — | EP | disclosed |
| US-4788206-A | CARDIOVASCULAR DISORDERS, PLATELETS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |
| US-4623660-A | ANTIESTROGENS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-11-18 | — | — | US | disclosed |
| EP-0002097-B1 | TRIPHENYLALKENE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-08-05 | — | — | EP | disclosed |
| EP-0002097-A1 | Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-05-30 | — | — | EP | disclosed |