Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.62 |
| ▸ | ALOX5AP | P20292 | 17/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 11/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | RECQL | P46063 | 3/20 | 0.58 |
| ▸ | BLM | P54132 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL167199 | 0.89 | PTGES2 (0.66) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL9044180 | 0.87 | PTGES2 (0.80) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL9254050 | 0.85 | ALOX5AP (0.63) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL9044519 | 0.84 | ALOX5AP (0.79) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL9581549 | 0.83 | PTGES2 (0.70) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL9447575 | 0.83 | ALOX5AP (0.79) | ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL12014953 | 0.83 | PTGES2 (0.57) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL1395500 | 0.82 | PTGES2 (0.53) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL10264786 | 0.81 | PTGES2 (0.56) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 | |
| SCHEMBL176187 | 0.81 | PTGES2 (0.56) | PTGES2ALOX5APALOX5CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0535925-B1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC (CA) | 1996-04-24 | — | — | EP | disclosed |
| US-5389650-A | Antiinflammatory agents, anticoagulants, antispasmodic agents | MERCK FROSST CANADA, INC. (CA) | 1995-02-14 | — | — | US | disclosed |
| WO-1994013662-A1 | (AZAARYLMETHOXY)INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1994-06-23 | — | — | WO | disclosed |
| US-5308850-A | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| US-5290798-A | Antihistamines, antiallergens, antiinflammatory agents | MERCK FROSST CANADA, INC. (CA) | 1994-03-01 | — | — | US | disclosed |
| US-5273980-A | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-12-28 | — | — | US | disclosed |
| WO-1993016069-A1 | (AZAAROMATICALKOXY)INDOLES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1993-08-19 | — | — | WO | disclosed |
| EP-0535924-A1 | (Bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535923-A1 | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535926-A1 | (Hetero-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| EP-0535925-A1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |
| US-5190968-A | Antiinflammatory | MERCK FROSST CANADA, INC. (CA) | 1993-03-02 | — | — | US | disclosed |