Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | FABP7 | O15540 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15538748 | 0.87 | TSHR (0.42) | HTR2AHTR2CHTR2BTAAR1LMNA | |
| SCHEMBL30444100 | 0.87 | TSHR (0.42) | HTR2AHTR2CHTR2BTAAR1LMNA | |
| SCHEMBL16795877 | 0.87 | TSHR (0.42) | HTR2AHTR2CHTR2BTAAR1LMNA | |
| SCHEMBL29418661 | 0.87 | TSHR (0.42) | HTR2AHTR2CHTR2BTAAR1LMNA | |
| SCHEMBL16808656 | 0.84 | SMN1; SMN2 (0.37) | HTR2AHTR2CHTR2BLMNATSHR | |
| SCHEMBL16808546 | 0.84 | SMN1; SMN2 (0.37) | HTR2AHTR2CHTR2BLMNATSHR | |
| SCHEMBL1498876 | 0.80 | HTR2A (0.42) | HTR2AHTR2CHTR2BDPP4TP53 | |
| SCHEMBL4077173 | 0.80 | SLC5A2 (0.43) | HTR2AHTR2CHTR2BDPP4TP53 | |
| SCHEMBL4087354 | 0.80 | SLC5A2 (0.43) | HTR2AHTR2CHTR2BDPP4TP53 | |
| SCHEMBL4087103 | 0.80 | SLC5A2 (0.43) | HTR2AHTR2CHTR2BDPP4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730593-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LTD. (GB) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014690-A1 | MORPHOLINE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1995-06-01 | — | — | WO | disclosed |