Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 12/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.54 |
| ▸ | TSHR | P16473 | 6/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318898 | 0.89 | OPRL1 (0.54) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL6377977 | 0.84 | CYP2D6 (0.55) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL31299394 | 0.82 | CYP2D6 (0.54) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL31299444 | 0.82 | CYP2D6 (0.54) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL3493144 | 0.82 | CYP2D6 (0.54) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL4023771 | 0.82 | OPRL1 (0.59) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL9048680 | 0.81 | CYP2D6 (0.52) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL6783749 | 0.81 | OPRL1 (0.58) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL11353776 | 0.81 | CYP2D6 (0.59) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 | |
| SCHEMBL8136038 | 0.79 | CYP2D6 (0.59) | CYP2D6ALDH1A1CYP3A4TSHRUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287356-B1 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1996-01-24 | — | — | EP | disclosed |
| US-5132316-A | Cognition activators | BEECHAM GROUP P.L.C. (GB) | 1992-07-21 | — | — | US | disclosed |
| US-4971975-A | TREATMENT OF DEMENTIA; AZABICYCLOOCTANE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1990-11-20 | — | — | US | disclosed |
| EP-0287356-A2 | Bridgehead substituted azabicyclic derivatives | BEECHAM GROUP PLC (GB) | 1988-10-19 | — | — | EP | disclosed |