Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.67 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.67 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.65 |
| ▸ | BCHE | P06276 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7066702 | 0.99 | CHRM3 (0.68) | CHRM3CHRM2CHRM1GAAATM | |
| Hydrochloric Acid SCHEMBL5003293 | 0.98 | CHRM3 (0.67) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5007163 | 0.90 | GAA (0.61) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5007129 | 0.86 | GAA (0.59) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL4084020 | 0.86 | GAA (0.70) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5006005 | 0.81 | GAA (0.58) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5009379 | 0.81 | GAA (0.64) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5007002 | 0.81 | GAA (0.58) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5003333 | 0.81 | GAA (0.58) | CHRM3CHRM2CHRM1GAAATM | |
| SCHEMBL5011132 | 0.81 | GAA (0.58) | CHRM3CHRM2CHRM1GAAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747355-A1 | NOVEL CARBAMATE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-12-11 | — | — | EP | disclosed |