⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17238958 | 1.00 | — | — | |
| SCHEMBL2653128 | 1.00 | — | — | |
| SCHEMBL31515508 | 0.77 | — | — | |
| SCHEMBL4865154 | 0.74 | — | — | |
| SCHEMBL2449200 | 0.74 | — | — | |
| SCHEMBL231118 | 0.74 | — | — | |
| SCHEMBL24484226 | 0.72 | — | — | |
| SCHEMBL4905058 | 0.72 | — | — | |
| SCHEMBL13147809 | 0.72 | — | — | |
| SCHEMBL27502023 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3183255-B1 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC (US) | 2023-07-05 | — | — | EP | disclosed |
| EP-3183255-B1 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC (US) | 2023-07-05 | — | — | EP | disclosed |
| US-9701685-B2 | Spiropyrrolidines as MDM2 inhibitors | HUDSON BIOPHARMA INC. (US) | 2017-07-11 | — | — | US | disclosed |
| US-9701685-B2 | Spiropyrrolidines as MDM2 inhibitors | HUDSON BIOPHARMA INC. (US) | 2017-07-11 | — | — | US | disclosed |
| EP-3183255-A2 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | Hudson Biopharma Inc. (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2016028391-A9 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016028391-A9 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC. (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016028391-A2 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC. (US) | 2016-02-25 | — | — | WO | disclosed |
| WO-2016028391-A2 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC. (US) | 2016-02-25 | — | — | WO | disclosed |
| US-20150322076-A1 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC. | 2015-11-12 | — | — | US | disclosed |
| US-20150322076-A1 | SPIROPYRROLIDINES AS MDM2 INHIBITORS | HUDSON BIOPHARMA INC. | 2015-11-12 | — | — | US | disclosed |
| WO-2012043619-A1 | ANTIBACTERIAL AGENT, SUBSTRATE SURFACE TREATMENT METHOD USING THE SAME, ANTIBACTERIAL AGENT COMPOSITION, AND SUBSTRATE SURFACE TREATMENT METHOD USING THE SAME | セントラル硝子株式会社 (JP) | 2012-04-05 | — | — | WO | disclosed |