⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11461024 | 0.67 | — | — | |
| SCHEMBL7975382 | 0.64 | — | — | |
| SCHEMBL7933276 | 0.61 | — | — | |
| SCHEMBL44990 | 0.61 | — | — | |
| SCHEMBL9135233 | 0.61 | — | — | |
| SCHEMBL4529855 | 0.61 | — | — | |
| SCHEMBL343501 | 0.61 | — | — | |
| SCHEMBL7068378 | 0.61 | — | — | |
| SCHEMBL10785348 | 0.61 | — | — | |
| SCHEMBL28133972 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 363 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210023094-A1 | PSMA ANTIBODY-DRUG CONJUGATES | PSMA DEVELOPMENT COMPANY, LLC (US) | 2021-01-28 | — | — | US | claimed |
| EP-2727606-A2 | Compounds for killing psma-expressing, taxane-resistant cancer cells | Psma Development Company, L.L.C. (US) | 2014-05-07 | — | — | EP | claimed |
| EP-1912677-B1 | PSMA antibody-drug conjugates | PSMA DEV COMPANY L L C (US) | 2013-10-02 | — | — | EP | claimed |
| EP-2326350-B1 | COMPOUNDS FOR KILLING PSMA-EXPRESSING, TAXANE-RESISTANT CANCER CELLS | PSMA DEV COMPANY L L C (US) | 2013-09-04 | — | — | EP | claimed |
| EP-1718667-B1 | HETEROCYCLIC SELF-IMMOLATIVE LINKERS AND CONJUGATES | GENENTECH INC (US) | 2013-01-09 | — | — | EP | claimed |
| EP-2326350-A2 | METHODS FOR KILLING PSMA-EXPRESSING, TAXANE-RESISTANT CANCER CELLS | Psma Development Company, L.L.C. (US) | 2011-06-01 | — | — | EP | claimed |
| US-7884053-B2 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation | BOSTON PROBES, INC. (US) | 2011-02-08 | — | — | US | claimed |
| US-7754681-B2 | Heterocyclic self-immolative linkers and conjugates | SEATTLE GENETICS, INC. (US) | 2010-07-13 | — | — | US | claimed |
| WO-2010027513-A2 | METHODS FOR KILLING PSMA-EXPRESSING, TAXANE-RESISTANT CANCER CELLS | PSMA DEVELOPMENT COMPANY, LLC (US) | 2010-03-11 | — | — | WO | claimed |
| JP-4408628-B2 | — | — | 2010-02-03 | — | — | JP | claimed |
| US-20050256030-A1 | for linking drug moieties to ligands; comprises a peptide sequence that is a substrate for an intracellular enzyme, for example a cathepsin, that cleaves the peptide at an amide bond | SEAGEN INC. | 2005-11-17 | — | — | US | claimed |
| WO-2005082023-A2 | HETEROCYCLIC SELF-IMMOLATIVE LINKERS AND CONJUGATES | GENENTECH, INC. (US) | 2005-09-09 | — | — | WO | claimed |
| JP-2004524032-A | — | — | 2004-08-12 | — | — | JP | claimed |
| EP-1412517-A4 | METHODS, KITS AND COMPOSITIONS OF COMBINATION OLIGOMERS | BOSTON PROBES INC (US) | 2004-07-07 | — | — | EP | claimed |
| EP-1412517-A2 | METHODS, KITS AND COMPOSITIONS OF COMBINATION OLIGOMERS | Boston Probes, Inc. (US) | 2004-04-28 | — | — | EP | claimed |
| US-20030077608-A1 | Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation | APPLIED BIOSYSTEMS, LLC | 2003-04-24 | — | — | US | claimed |
| WO-2002072865-A2 | METHODS, KITS AND COMPOSITIONS OF COMBINATION OLIGOMERS | BOSTON PROBES, INC. (US) | 2002-09-19 | — | — | WO | claimed |
| EP-0624377-B1 | Lysosomal enzyme-cleavable antitumor drug conjugates | BRISTOL MYERS SQUIBB CO (US) | 2002-01-23 | — | — | EP | claimed |
| US-6214345-B1 | ANTITUMOR AGENTS; DRUG CONJUGATES WHICH ARE SELECTIVELY ACTIVATIBLE AT THE SITE OF THE TUMOR | BRISTOL-MYERS SQUIBB CO. | 2001-04-10 | — | — | US | claimed |
| EP-0624377-A2 | Lysosomal enzyme-cleavable antitumor drug conjugates | Bristol-Myers Squibb Company (US) | 1994-11-17 | — | — | EP | claimed |