Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053090 | 1.00 | KMT2A (0.46) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL769600 | 1.00 | KMT2A (0.46) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL3197183 | 0.94 | KMT2A (0.44) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL3197180 | 0.94 | KMT2A (0.44) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL15099775 | 0.84 | KMT2A (0.47) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL20183376 | 0.84 | KMT2A (0.47) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL20183374 | 0.84 | KMT2A (0.47) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL20183457 | 0.84 | KMT2A (0.47) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL3194067 | 0.84 | KMT2A (0.47) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD | |
| SCHEMBL20183458 | 0.84 | KMT2A (0.47) | KMT2AHSD11B1CYP2D6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| US-RE41149-E1 | Stereoisomerically pure 7-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-6-fluoro-1-[(1R,2S)-2-fluoro-1-cyclopropyl]-8-methoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid or a pharmaceutically acceptable salt thereof; antibacterial agents | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-02-23 | — | — | US | disclosed |
| WO-1996039407-A1 | QUINOLIZINONE TYPE COMPOUNDS | ABBOTT LABORATORIES (US) | 1996-12-12 | — | — | WO | disclosed |