Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.55 |
| ▸ | EDNRB | P24530 | 8/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD2 | P25440 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053721 | 0.91 | EDNRA (0.65) | EDNRAEDNRB | |
| SCHEMBL9052684 | 0.84 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL9046557 | 0.83 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL9045379 | 0.81 | EDNRA (0.76) | EDNRAEDNRB | |
| SCHEMBL9044771 | 0.79 | EDNRA (0.82) | EDNRAEDNRB | |
| SCHEMBL9046585 | 0.78 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL9495260 | 0.78 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL9045519 | 0.77 | EDNRA (0.66) | EDNRAEDNRBALDH1A1 | |
| SCHEMBL9046504 | 0.77 | EDNRA (0.69) | EDNRAEDNRB | |
| SCHEMBL7324606 | 0.77 | EDNRA (0.45) | EDNRAEDNRBBRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | claimed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | claimed |
| EP-0510526-B1 | Use of sulfonamides as drug and new sulfonamides | HOFFMANN LA ROCHE (CH) | 1996-12-04 | — | — | EP | disclosed |
| EP-0510526-A1 | Use of sulfonamides as drug and new sulfonamides | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1992-10-28 | — | — | EP | disclosed |