Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | CNOT7 | Q9UIV1 | 6/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7561563 | 0.94 | POLB (0.55) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL10346505 | 0.92 | POLB (0.69) | ALDH1A1SMN1; SMN2POLBHIF1ATSHR | |
| SCHEMBL7559639 | 0.91 | POLB (0.68) | ALDH1A1SMN1; SMN2POLBHIF1ATSHR | |
| SCHEMBL7561501 | 0.91 | POLB (0.56) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL9054420 | 0.90 | KMT2A (0.52) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL7562065 | 0.88 | POLB (0.71) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL7563973 | 0.86 | POLB (0.58) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL7560381 | 0.86 | POLB (0.53) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL7559268 | 0.84 | POLB (0.73) | ALDH1A1SMN1; SMN2POLBHIF1AKMT2A | |
| SCHEMBL7563991 | 0.83 | POLB (0.66) | ALDH1A1SMN1; SMN2POLBHIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0528164-B1 | Use of xanthine derivatives for the manufacture of a medicament for the treatment of secondary nerve cell damages and function disorders after head-brain-traumata | HOECHST AG (DE) | 1996-05-29 | — | — | EP | disclosed |
| US-5409935-A | Inhibit formation of free radicals | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-25 | — | — | US | disclosed |
| EP-0528164-A2 | Use of xanthine derivatives for the manufacture of a medicament for the treatment of secondary nerve cell damages and function disorders after head-brain-traumata | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-02-24 | — | — | EP | disclosed |