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Erythromycin

Erythromycin

SCHEMBL9054352

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nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 8/20 0.95
▸ KCNH2 Q12809 5/20 0.95
▸ MLNR O43193 3/20 0.95
▸ ABCB1 P08183 2/20 0.95
▸ TSHR P16473 2/20 0.95
▸ LMNA P02545 2/20 0.95
▸ TDP1 Q9NUW8 1/20 0.95
▸ ALB P02768 1/20 0.95
▸ CNR1 P21554 1/20 0.95
▸ HTR2A P28223 1/20 0.95
▸ AOX1 Q06278 1/20 0.95
▸ CYP1B1 Q16678 1/20 0.95
▸ SLCO1B3 Q9NPD5 2/20 0.88
▸ SLCO1B1 Q9Y6L6 2/20 0.88
▸ AR P10275 1/20 0.88
▸ MAPK1 P28482 1/20 0.88
▸ PGR P06401 1/20 0.82
▸ HTR1A P08908 1/20 0.82
▸ DRD1 P21728 1/20 0.82
▸ SLC6A2 P23975 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Erythromycin SCHEMBL10900217 1.00 CYP3A4 (0.95) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL10708612 0.99 CYP3A4 (0.94) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL10708608 0.99 CYP3A4 (0.94) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL11201590 0.98 CYP3A4 (0.96) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL6395349 0.98 CYP3A4 (0.96) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL11503675 0.98 CYP3A4 (0.96) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL27995474 0.97 CYP3A4 (0.95) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL4776718 0.97 CYP3A4 (0.95) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL24415240 0.97 CYP3A4 (1.00) CYP3A4KCNH2MLNRABCB1TSHR
Erythromycin SCHEMBL13900514 0.97 CYP3A4 (1.00) CYP3A4KCNH2MLNRABCB1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115003309-B Crystal form of compound with structural formula I 阿里量子解决方法公司 2024-05-24 — — CN disclosed
CN-110582286-B Ocular application of matrix-bound vesicles (MBVs) 联邦高等教育系统匹兹堡大学 2024-01-30 — — CN disclosed
CN-113853185-A Implantable ocular drug delivery devices and methods 迈克罗欧普提克斯股份有限公司 2021-12-28 — — CN disclosed
CN-112912386-A Cell penetrating peptide based on influenza virus M2 protein 中国医学科学院基础医学研究所 2021-06-04 — — CN disclosed
CN-112107738-A Novel coronary artery plugging balloon 浙江桐轩医疗科技有限公司 2020-12-22 — — CN disclosed
CN-1219788-C Dynamic controlled crystalline method of preparing erythromycin from erythromysin salt UNIV EAST CHINA SCIENCE & TECH (CN) 2005-09-21 — — CN disclosed
CN-1513864-A Dynamic controlled crystalline method of preparing erythromycin from erythromysin salt 华东理工大学 2004-07-21 — — CN disclosed
WO-1996008502-A1 PREPARATION OF (8S)-8-FLUOROERYTHROMYCINS WITH N-F FLUORINATING AGENTS ALLIEDSIGNAL INC. (US) 1996-03-21 — — WO disclosed
US-4599326-A ANTIBIOTIC, GOOD ABSORBABILITY/ ORION-YHTYMA OY (FI) 1986-07-08 — — US disclosed