Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CCL2 | P13500 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9055496 | 0.87 | HTR2A (0.38) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL3381093 | 0.82 | HTR2A (0.40) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL11474871 | 0.74 | HTR2A (0.38) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL3383295 | 0.74 | HTR2A (0.38) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL3382953 | 0.74 | HTR2A (0.38) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL11475155 | 0.71 | RET (0.37) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL8693899 | 0.70 | HTR2A (0.41) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL197033 | 0.70 | HTR2A (0.41) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL31297722 | 0.70 | HTR2A (0.41) | HTR2AHTR6RETCYP2D6SIGMAR1 | |
| SCHEMBL30990099 | 0.70 | HTR2A (0.41) | HTR2AHTR6RETCYP2D6SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996013531-A1 | PREPARATION OF MODIFIED POLYOLEFIN CATALYSTS AND IN SITU PREPARATION OF SUPPORTED METALLOCENE AND ZIEGLER-NATTA/METALLOCENE POLYOLEFIN CATALYSTS | W.R. GRACE & CO.-CONN. (US) | 1996-05-09 | — | — | WO | claimed |
| WO-1996013531-A1 | PREPARATION OF MODIFIED POLYOLEFIN CATALYSTS AND IN SITU PREPARATION OF SUPPORTED METALLOCENE AND ZIEGLER-NATTA/METALLOCENE POLYOLEFIN CATALYSTS | W.R. GRACE & CO.-CONN. (US) | 1996-05-09 | — | — | WO | disclosed |