Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 7/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8765043 | 0.79 | GAA (0.54) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11398860 | 0.78 | GAA (0.74) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL17206979 | 0.77 | GAA (0.51) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11569757 | 0.75 | GAA (0.57) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13879573 | 0.75 | GAA (0.78) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL13879431 | 0.74 | CYP3A4 (0.50) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9054894 | 0.74 | GAA (0.46) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL11613982 | 0.73 | GAA (0.54) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| Bromide SCHEMBL11612764 | 0.73 | GAA (0.45) | GAAMAPTCYP1A2CYP3A4CYP2C19 | |
| Iodide SCHEMBL11613376 | 0.73 | GAA (0.45) | GAAMAPTCYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511558-B1 | Process for the resolution of racemates and associates of diastereoisomers | HOFFMANN LA ROCHE (CH) | 1996-10-23 | — | — | EP | claimed |
| US-5334766-A | Process for the resolution of racemic diphosphine oxides | HOFFMANN-LA ROCHE INC. (US) | 1994-08-02 | — | — | US | claimed |
| EP-0511558-A2 | Process for the resolution of racemates and associates of diastereoisomers | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-04 | — | — | EP | claimed |
| EP-0511558-B1 | Process for the resolution of racemates and associates of diastereoisomers | HOFFMANN LA ROCHE (CH) | 1996-10-23 | — | — | EP | disclosed |
| US-5334766-A | Process for the resolution of racemic diphosphine oxides | HOFFMANN-LA ROCHE INC. (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0511558-A2 | Process for the resolution of racemates and associates of diastereoisomers | F. HOFFMANN-LA ROCHE AG (CH) | 1992-11-04 | — | — | EP | disclosed |