Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 12/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 12/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8758572 | 1.00 | ADRB3 (0.58) | ADRB3ADRB2ADRB1ADRA1ANR3C1 | |
| SCHEMBL9055982 | 1.00 | ADRB3 (0.58) | ADRB3ADRB2ADRB1ADRA1ANR3C1 | |
| SCHEMBL29900811 | 0.89 | ADRB3 (0.74) | ADRB3ADRB2ADRB1 | |
| SCHEMBL8758065 | 0.89 | ADRB3 (0.74) | ADRB3ADRB2ADRB1 | |
| SCHEMBL8758071 | 0.89 | ADRB3 (0.54) | ADRB3ADRB2ADRB1ADRA1ANR3C1 | |
| SCHEMBL8758031 | 0.89 | ADRB3 (0.54) | ADRB3ADRB2ADRB1ADRA1ANR3C1 | |
| SCHEMBL8758042 | 0.89 | ADRB3 (0.54) | ADRB3ADRB2ADRB1ADRA1ANR3C1 | |
| SCHEMBL8757456 | 0.89 | ADRB3 (0.59) | ADRB3ADRB2ADRB1CYP2D6 | |
| SCHEMBL8758081 | 0.89 | ADRB3 (0.70) | ADRB3ADRB2ADRB1CYP2D6 | |
| SCHEMBL8757462 | 0.89 | ADRB3 (0.59) | ADRB3ADRB2ADRB1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996004234-A1 | ARYLOXY ANDARYCTHIO PROPANOLAMINE DERIVATIVES USEFUL AS B3-ADRENORECEPTOR AGONISTS AND ANTAGONS OF THE B1 AND B2 ADRENORECEPTORS AND PHARMACEUTICAL COMPOSITION THEREOF | SMITHKLINE BEECHAM PLC (GB) | 1996-02-15 | — | — | WO | disclosed |