Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 8/20 | 0.64 |
| ▸ | HTR1D | P28221 | 5/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | HTR6 | P50406 | 10/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593919 | 0.86 | HTR1B (0.69) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8914034 | 0.84 | HTR1B (0.61) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8914038 | 0.84 | HTR1B (0.61) | HTR1BHTR1DHTR1AHTR6 | |
| SCHEMBL8789559 | 0.83 | HTR1B (0.62) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8790208 | 0.83 | HTR1B (0.62) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8790203 | 0.83 | HTR1B (0.62) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8479254 | 0.83 | HTR1B (0.71) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8479248 | 0.83 | HTR1B (0.71) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8914371 | 0.82 | HTR1B (0.61) | HTR1BHTR1DHTR1AHTR6CHRM2 | |
| SCHEMBL8914376 | 0.82 | HTR1B (0.61) | HTR1BHTR1DHTR1AHTR6CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |
| WO-1994024127-A1 | INDOLE DERIVATIVES AS 5-H1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LIMITED (GB) | 1994-10-27 | — | — | WO | disclosed |