Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.73 |
| ▸ | CSF1R | P07333 | 1/20 | 0.72 |
| ▸ | RET | P07949 | 2/20 | 0.59 |
| ▸ | KIF5B | P33176 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 6/20 | 0.58 |
| ▸ | BACE1 | P56817 | 6/20 | 0.58 |
| ▸ | KIT | P10721 | 3/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8652234 | 0.99 | EGFR (0.74) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL5461541 | 0.93 | EGFR (0.64) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL4759922 | 0.92 | EGFR (0.63) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL9052748 | 0.87 | EGFR (0.75) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL9053074 | 0.87 | EGFR (0.75) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8644637 | 0.87 | EGFR (0.75) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL8650196 | 0.86 | EGFR (0.73) | EGFRCSF1RRETKIF5BKDR | |
| Hydrochloric Acid SCHEMBL8649141 | 0.86 | EGFR (0.76) | EGFRCSF1RRETKIF5BKDR | |
| SCHEMBL9057163 | 0.86 | EGFR (0.73) | EGFRCSF1RRETKIF5BKDR | |
| Hydrochloric Acid SCHEMBL8647412 | 0.86 | EGFR (0.76) | EGFRCSF1RRETKIF5BKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0746554-A1 | 4-HETEROCYCLYL-SUBSTITUTED QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS ANTI-CANCER AGENTS | PFIZER INC. (US) | 1996-12-11 | — | — | EP | disclosed |