Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057632 | 0.82 | KDM4E (0.43) | KDM4EMAPTTHRBHPGDGPR119 | |
| Hydrochloric Acid SCHEMBL9055449 | 0.80 | KDM4E (0.39) | KDM4EMAPTTHRBFAAHHPGD | |
| SCHEMBL792459 | 0.70 | HPGD (0.54) | KDM4EFAAHHPGDGPR119RECQL | |
| Ammonia Solution, Strong SCHEMBL7868695 | 0.69 | HPGD (0.53) | KDM4EFAAHHPGDGPR119RECQL | |
| SCHEMBL12844537 | 0.67 | NR1H2 (0.48) | KDM4EMAPTFAAHHPGDGPR119 | |
| SCHEMBL19347041 | 0.67 | NR1H2 (0.48) | KDM4EMAPTFAAHHPGDGPR119 | |
| SCHEMBL16609042 | 0.67 | NR1H2 (0.48) | KDM4EMAPTFAAHHPGDGPR119 | |
| SCHEMBL10219106 | 0.66 | NR1H2 (0.41) | KDM4EMAPTTHRBHPGDRECQL | |
| SCHEMBL10219104 | 0.66 | NR1H2 (0.41) | KDM4EMAPTTHRBHPGDRECQL | |
| SCHEMBL1468234 | 0.66 | NR1H2 (0.41) | KDM4EMAPTTHRBHPGDRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996014844-A1 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-05-23 | — | — | WO | disclosed |