Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.96 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.96 |
| ▸ | GPR84 | Q9NQS5 | 9/20 | 0.68 |
| ▸ | PPARG | P37231 | 7/20 | 0.68 |
| ▸ | PPARD | Q03181 | 7/20 | 0.68 |
| ▸ | PPARA | Q07869 | 7/20 | 0.68 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 4/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TLR2 | O60603 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | FABP4 | P15090 | 2/20 | 0.68 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.68 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ESR1 | P03372 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | PDE4A | P27815 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Palmitic Acid SCHEMBL20818808 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL22400867 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL22400864 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| Sebacic Acid SCHEMBL25270035 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL22400945 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| Azelaic Acid SCHEMBL25433337 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| Palmitic Acid SCHEMBL21526666 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL25190974 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL20587804 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD | |
| SCHEMBL22400948 | 0.98 | FFAR4 (1.00) | FFAR4FFAR1GPR84PPARGPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996022270-A1 | BIOPOLYMERS DERIVED FROM HYDROLYZABLE DIACID FATS | YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1996-07-25 | — | — | WO | claimed |
| US-5473103-A | POLYESTERS, POLYANHYDRIDES | YISSUM RESEARCH DEVELOPMENT CO. OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1995-12-05 | — | — | US | claimed |
| CN-107960105-B | Efficient oxalate degrading enzyme for degrading insoluble and soluble oxalic acid | 武汉康复得生物科技股份有限公司 | 2025-05-16 | — | — | CN | disclosed |
| EP-3277099-B9 | HIGH EFFICIENCY OXALATE-DEGRADING ENZYMES FOR DEGRADATION OF INSOLUBLE AND SOLUBLE OXALATE | OXIDIEN PHARMACEUTICALS LLC (US) | 2024-05-29 | — | — | EP | disclosed |
| EP-3277099-B1 | HIGH EFFICIENCY OXALATE-DEGRADING ENZYMES FOR DEGRADATION OF INSOLUBLE AND SOLUBLE OXALATE | OXIDIEN PHARMACEUTICALS LLC (US) | 2023-11-08 | — | — | EP | disclosed |
| US-11603524-B2 | High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate | OXIDIEN PHARMACEUTICALS, LLC (US) | 2023-03-14 | — | — | US | disclosed |
| US-20220298497-A1 | HIGH EFFICIENCY OXALATE-DEGRADING ENZYMES FOR DEGRADATION OF INSOLUBLE AND SOLUBLE OXALATE | ORENZYMES LLC | 2022-09-22 | — | — | US | disclosed |
| US-20180362955-A1 | HIGH EFFICIENCY OXALATE-DEGRADING ENZYMES FOR DEGRADATION OF INSOLUBLE AND SOLUBLE OXALATE | ORENZYMES LLC | 2018-12-20 | — | — | US | disclosed |
| EP-3277099-A2 | HIGH EFFICIENCY OXALATE-DEGRADING ENZYMES FOR DEGRADATION OF INSOLUBLE AND SOLUBLE OXALATE | Captozyme, LLC (US) | 2018-02-07 | — | — | EP | disclosed |
| WO-2016161455-A2 | HIGH EFFICIENCY OXALATE-DEGRADING ENZYMES FOR DEGRADATION OF INSOLUBLE AND SOLUBLE OXALATE | CAPTOZYME, LLC (US) | 2016-10-06 | — | — | WO | disclosed |