Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.33 |
| ▸ | STAT3 | P40763 | 3/20 | 0.33 |
| ▸ | STAT1 | P42224 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8465253 | 0.86 | MAPT (0.37) | MAPTSMN1; SMN2HPGDNPSR1S1PR4 | |
| SCHEMBL8752074 | 0.72 | AURKA (0.39) | MAPTSMN1; SMN2HPGDNPSR1S1PR4 | |
| SCHEMBL8463021 | 0.71 | HPGD (0.35) | MAPTSMN1; SMN2HPGDNPSR1S1PR4 | |
| SCHEMBL7024116 | 0.70 | KMT2A (0.35) | MAPTSMN1; SMN2HPGDNPSR1S1PR4 | |
| SCHEMBL7018634 | 0.68 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2HPGDNPSR1S1PR4 | |
| SCHEMBL8466939 | 0.64 | — | — | |
| SCHEMBL7021256 | 0.64 | CA1 (0.40) | SMN1; SMN2LMNAKMT2AKDM4EALDH1A1 | |
| SCHEMBL7017964 | 0.64 | NPC1 (0.41) | SMN1; SMN2HPGDKDM4EALDH1A1RAB9A | |
| SCHEMBL8466328 | 0.64 | PDE10A (0.49) | — | |
| SCHEMBL7022757 | 0.64 | NOTUM (0.41) | SMN1; SMN2HPGDLMNATP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0749433-A1 | (4,4-DIFLUOROBUT-3-ENYLTHIO)-SUBSTITUTED HETEROCYCLIC OR CARBOCYCLIC RING COMPOUNDS HAVING PESTICIDAL ACTIVITY | ZENECA LIMITED (GB) | 1996-12-27 | — | — | EP | disclosed |