⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008275 | 0.69 | — | — | |
| SCHEMBL5237307 | 0.69 | — | — | |
| SCHEMBL6141280 | 0.67 | — | — | |
| SCHEMBL514125 | 0.67 | — | — | |
| SCHEMBL8751731 | 0.66 | — | — | |
| SCHEMBL26622217 | 0.65 | — | — | |
| SCHEMBL3898888 | 0.63 | — | — | |
| SCHEMBL129174 | 0.62 | — | — | |
| SCHEMBL7198 | 0.62 | — | — | |
| SCHEMBL7249189 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277520-A2 | A pharmaceutical composition for angiotensin ii-mediated diseases | Takeda Pharmaceutical Company Limited (JP) | 2011-01-26 | — | — | EP | disclosed |
| EP-1844774-A2 | A pharmaceutical composition for angiotensin II-mediated diseases | Takeda Pharmaceutical Company Limited (JP) | 2007-10-17 | — | — | EP | disclosed |
| US-7135490-B2 | Using an imidazole compound | TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2006-11-14 | — | — | US | disclosed |
| US-20040082636-A1 | Method for the prophylaxis or treatment of glomerulonephritis | TAKEDA CHEMICAL INDUSTRIES, LTD. | 2004-04-29 | — | — | US | disclosed |
| US-6686383-B2 | TREATMENT OF DIABETIC NEPHROPATHY WITH A BIPHENYL-4-YL)ALKYL-1H-BENZIMIDAZOLE COMPOUNDS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 2004-02-03 | — | — | US | disclosed |
| US-20030114509-A1 | Prophylactic or therapeutic drug for renal diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. | 2003-06-19 | — | — | US | disclosed |
| EP-1306088-A1 | Combination of a benzimidazole having angiotensin-II antagonistic activity with a diuretic | Takeda Chemical Industries, Ltd. (JP) | 2003-05-02 | — | — | EP | disclosed |
| EP-1306089-A1 | Combination of benzimidazoles having angiotensin-II antagonistic activity with diuretics or calcium antagonists | Takeda Chemical Industries, Ltd. (JP) | 2003-05-02 | — | — | EP | disclosed |
| US-6469037-B2 | Prophylactic or therapeutic drug for renal diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6420405-B2 | MIXTURE WITH DIURETIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| US-20010011098-A1 | Pharmaceutical composition for angiotensin II-mediated diseases | TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2001-08-02 | — | — | US | disclosed |
| US-20010004640-A1 | Pharmaceutical composition for angiotensin II-mediated diseases | TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2001-06-21 | — | — | US | disclosed |
| US-6228874-B1 | 1-(BIPHENYL-4-YL)METHYL-1H-BENZIMIDAZOLE-7-CARBOXYLATE DERIVATIVE MIXTURE WITH FUROSEMIDE; SIDE EFFECT REDUCTION; DIURETICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-08 | — | — | US | disclosed |
| US-6040324-A | TREATING DIABETIC NEPHROPATHY OR GLOMERULONEPHRITIS WITH AN ANGIOTENSIN II ANTAGONISTIC COMPOUND | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5958961-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| US-5889036-A | ADMINISTERING 2-ETHOXY-1-((2'-(4,5-DIHYDRO-5-OXO-1,2,4-OXADIAZOL-3-YL)-BIPHE NYL)METHYL-1H-BENZIMIDAZOL-7-CARBOXYLIC ACID | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-30 | — | — | US | disclosed |
| US-5721263-A | ANGIOTENSIN II ANTAGONIST IN COMBINATION WITH DIURETIC OR CALCIUM ANTAGONIST; TREATING HYPERTENSION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-24 | — | — | US | disclosed |
| EP-0753301-A1 | Combination of benzimidazoles having angiotensin-II antagonistic activity with diuretics | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-15 | — | — | EP | disclosed |
| EP-0628313-A1 | Combination of benzimidazoles having angiotensin-II antagonistic activity with dinretics or calcium antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-12-14 | — | — | EP | disclosed |
| EP-0622077-A1 | Angiotensin II antagonists as a prophylactic or therapeutic drug for renal diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-11-02 | — | — | EP | disclosed |